[2] Enteroviruses have a depression encircling each fivefold axis (canyon), which is their binding site for immunoglobulin-like receptors.

In others, infection produces short-lived (7–10 days) fever and painful blisters in the mouth (a condition known as herpangina), on the palms and fingers of the hand, or on the soles of the feet.

[8] Other diseases include acute haemorrhagic conjunctivitis (A24 specifically), herpangina, and aseptic meningitis (both Coxsackie A and B viruses).

People who are infected may present with a mild fever and sore throat, and a general discomfort three to six days subsequent to exposure.

These sores usually appear 24 hours after the flu like symptoms begin, and may blister, causing further discomfort when eating or drinking.

A flat, red skin rash may appear, commonly accompanied by fluid filled blisters and scabbing.

Rash will commonly present on the bottom of the feet, palm of hands, and other areas of the body, and persists upwards to ten days.

Other serious complications include inflammatory brain conditions, such as viral meningitis or encephalitis, which require medical intervention.

[11] A professional health care may need to monitor if the someone infected is immunocompromised, or the symptoms do not improve within ten days.

[14] In Finland, the initial HFMD case caused by the CVA6 lead to its identification of being the responsible pathogen of the outbreaks in Europe, North America, and Asia.

[20] There have been reports of congenital heart defects and urogenital anomalies within the newborns of women who seroconverted to CVB during pregnancy.

[citation needed] The modes of transmission of the Coxsackie virus is primarily through contact between people, respiratory droplets (fluid from coughing and sneezing), and contaminated surfaces.

Complications include stomatitis, meningitis, pulmonary edema, myocarditis, pneumonia, and possibly spontaneous abortions.

NSAIDs such as ibuprofen/naproxen and acetaminophen can be used to manage the flu-like symptoms, fever, and any other pain the infected individual may be feeling.

Additionally, topical oral analgesic medications or salt water rinses can be used to help numb the sores and ease the throat pain.