The studio was founded under Sony Computer Entertainment in July 1997 through the buyout of the game development division of CyberLife Technology.

[1][2] Founded in 1996, CyberLife had previously developed games under the name "Millennium Interactive", including Diggers and Creatures, but changed its name early on when developing artificial intelligence technology and "artificial life" simulations became its primary focus.

[3][5] CyberLife would later change its name to Creature Labs in November 1999 before shutting down 2003, with some assets and staff acquired by Gameware Development.

[7] An undisclosed number of staffers were let go from Guerrilla Cambridge and other United Kingdom-based studios owned by SCE in March 2014.

[8] Guerrilla Cambridge was closed down on 12 January 2017 as a result of a regular review process within SCE's Worldwide Studios division.