He played college football for the Oklahoma Sooners, where he was named the Big 12 Conference's offensive lineman of the year in 2019 and 2020.

He initially committed to Texas A&M in June 2016 but decommitted two months later and signed a National Letter of Intent with Oklahoma.

[7][8][9] He returned as the starting center for Oklahoma in 2019 and 2020, being named the Big 12 Conference's offensive lineman of the year in both seasons.

On November 3, 2021, the midway point of the 2021 season, Pro Football Focus named Humphrey to their mid-season All-Rookie[17] and All-Pro teams.

[20] He helped the Chiefs win Super Bowl LVII against the Philadelphia Eagles 38–35, by anchoring the offensive line that allowed no sacks during the game.