Rising at Wyndmoor in Springfield Township (in a park near the USDA's Agricultural Research Service Eastern Regional Research Center, adjacent to the border between Montgomery County and Northwest Philadelphia), it runs about 2.7 miles (4.3 km) southwest, passing through part of Northwest Philadelphia and forming the boundary between Mount Airy and Chestnut Hill, before emptying into the Wissahickon Creek at Devil's Pool not far south of the Valley Green Inn.
In October 2013, the City of Philadelphia extended Fairmount Park ownership of the creek valley almost to the Philadelphia-Montgomery border at Stenton Avenue as part of the Wissahickon East Project, with ongoing and future efforts such as streambed cleanup and invasive species removal to restore the 6 acres (2.4 ha) of newly acquired land.
[1][2] Cresheim Valley Drive runs beside the creek from Stenton Avenue until southwest of the Chestnut Hill West Line tracks, where the road bends away to become Emlen Street.
A dirt parking area off Cresheim Valley Drive, southwest from the Chestnut Hill West railroad bridge, marks the trailhead for a set of walking paths that follow the creek for some distance downstream to its outlet.
[3] Outdoor enthusiasts of Northwest Philadelphia and various Montgomery County communities have encouraged their local legislators to effect the conversion of the Cresheim Branch's railbed into a rail trail.