[2] The county was created on August 17, 1905, from Dooly County and named for Georgia Congressman Charles Frederick Crisp.

[3][4] Crisp County comprises the Cordele, GA micropolitan statistical area.

According to the U.S. Census Bureau, the county has a total area of 281 square miles (730 km2), of which 273 square miles (710 km2) is land and 8.4 square miles (22 km2) (3.0%) is water.

[5] The western two-thirds of Crisp County, bordered on the east by a line from south of Arabi running northeast, is located in the Middle Flint River sub-basin of the ACF River Basin (Apalachicola-Chattahoochee-Flint River Basin).

[6] As of the 2020 United States census, there were 20,128 people, 8,585 households, and 5,712 families residing in the county.