[2] Her films have collectively earned ₱1.05 billion, making her one of the highest grossing Filipino box office stars this century.

[7] Reyes is recognized as a sex symbol,[8] with FHM Philippines crowning her as 2009's sexiest woman in the world, winning against Marian Rivera, Katrina Halili & Angel Locsin.

She went on to play minor roles in hit TV shows like Mulawin (2004), Darna (2005), and Marimar (2007).

[15] Reyes played daring roles in TV shows such as Eva Fonda (2008) and Tubig at Langis (2016).

[16] She made her breakthrough as a scorned wife in her lead film, No Other Woman (2011), co-starring Anne Curtis and Derek Ramsay.

Cristine had also been linked to Joross Gamboa, Keempee de Leon, and Mark Herras.

[19] Reyes gave birth to her first child, a daughter named Amarah, with her boyfriend Ali Khatibi, a mixed martial artist, on February 8, 2015.

[20] The couple married in a private ceremony on January 27, 2016, in Balesin Island, Polillo, Quezon.