Her performances in Darna (2005 & 2009), Majika (2006), Marimar (2007), the International Emmy nominated Magdusa Ka (2008),[1] Destiny Rose (2015), Sa Piling ni Nanay (2016), The Stepdaughters (2018) and Prima Donnas (2019) established her as one of the leading actresses in soap operas, mostly portraying antagonist roles.

Katrina Halili is an alumna of the StarStruck talent search and the cover girl of magazines such as FHM and Maxim Philippines.

Halili's non-showbiz partner Jeremy G. Guiab, former vice mayor of Wao, Lanao del Sur succumbed to a heart attack at age 53 on January 29, 2024.

[4] Halili started her first soap drama way back 2004 (Forever in My Heart) where she played Janelle Bernabe, the antagonist to the character of Jennylyn Mercado.

This made Katrina more famous as she was given her first lead role after Marimar this was the 2008 Magdusa Ka, she portrayed Christine, a headstrong waitress and prostitute who turns out to be a rich lass but was opposed by the evil Millet (played by Iwa Moto).

Another series is Magkano Ba ang Pag-ibig?, she played Margot, the scheming and hard-hearted sister of Lualhati who killed her mother out of anger, she also hated Eloisa.

Later in 2016, Halili played another main antagonist role in Sa Piling ni Nanay as Scarlet, the socialite evil mother of Katherine who tried to kill Ysabel and even her daughter as a revenge.

In November 2018, Halili joined the series Pamilya Roces, she played Maisa, the villainous daughter of Virgil, a seductive and ruthless serial killer who wants revenge for her mother's death.

Georgina firstly appeared as a cold-hearted and seductive woman but in reality she is kind and was a victim of the latter's cruelty as Dyna and the Generoso's killed her father.

She later played another protagonist role in Prima Donnas as Lillian Madreal, the surrogate mother of the triplets, Mayi, Ella, and Lenlen.