The series tells the story of Cubitus, a good-natured large, white dog endowed with speech.

He lives in a house in the suburbs with his master, Sémaphore, a retired sailor, next door to Sénéchal, the black and white cat who is Cubitus' nemesis.

Some of the single gag albums or short story compilations are thematic, with for instance in "Cubitus illustre ses ancêtres" revisiting history of humankind, "L'ami ne fait pas le moine" being pastiches of fellow authors from Tintin magazine or Les enquêtes de l'inspecteur Cubitus where he is a fictional police inspector.

[4] In 2005, the series was relaunched by Pierre Aucaigne (scenarist), and Michel Rodrigue (artist) under the title Les nouvelles aventures de Cubitus.

In 1977, the strip was adapted into a animated short film pilot by the Belgian studio Belvision, featuring the voices of André Gevrey, Georges Pradez and Guy Pion.