It also serves other nearby settlements, namely Goffs Oak, Northaw and the west of Cheshunt.

The station opened in 1910 on the Hertford Loop Line between Enfield Chase and Hertford North as Cuffley and Goff's Oak, with the suffix being dropped some time later.

The opening of the station allowed Cuffley to expand as an attractive commuter village with regular services to London King's Cross, and Broad Street (replaced by Northern City Line trains to Moorgate in 1976).

Cuffley was served by steam locomotives until 1960 when they were replaced by diesels; the line was electrified in 1976.

All services at Cuffley are operated by Great Northern using Class 717 EMUs.