[6] Sela Ward, who would return as the main recurring character of season two, appeared in the final two episodes as Stacy Warner, House's former girlfriend.
[7] Andrew Airlie, John Patrick Amedori, Skye McCole Bartusiak, Patrick Bauchau, Nicole Bilderback, Brandy, Hedy Burress, Nestor Carbonell, Ever Carradine, John Cho, Sarah Clarke, David Conrad, Christina Cox, Missy Crider, Myndy Crist, Nicholas D'Agosto, Ann Dowd, Stacy Edwards, Carmen Electra, Cynthia Ettinger, Scott Foley, Erin Foster, Kurt Fuller, Wendy Gazelle, Michael A. Goorjian, Peter Graves, Stanislav Grof, Mark Harelik, Roxanne Hart, David Henrie, Aaron Himelstein, Marin Hinkle, Leslie Hope, Lucinda Jenney, Andrew Keegan, Shirley Knight, Harry Lennix, Eddie McClintock, Scott Mechlowicz, Tracy Middendorf, Elizabeth Mitchell, Meredith Monroe, Joe Morton, Danny Nucci, Faith Prince, Dominic Purcell, Daryl Sabara, Amanda Seyfried, Alex Skuby, Jennifer Stone, Robin Thomas, Sam Trammell, Robin Tunney, Kristoffer Ryan Winters, Kevin Zegers, and Josh Zuckerman.
This resulted in his first Emmy Award nomination, for Outstanding Lead Actor in a Drama Series for his role as Dr. Gregory House.
When Dr. Lisa Cuddy tries to make House fulfill his clinical duties, he refuses but is forced to do them when his authorization to the MRI is revoked.
When Rebecca refuses treatment, House persuades her otherwise by proving her condition with a non-invasive X-ray suggested by Dr. Robert Chase, which depicts a tapeworm larva embedded in her leg, supporting their diagnosis.
House flashbacks to a case he had earlier that involved a mother who did not want her baby to be vaccinated and theorizes that Dan is suffering from a measles virus contracted during his childhood.
House gives Brandon the cure, and he immediately begins to recover, though nobody believes the pharmacist made a mistake.
However, when the kidneys of two of the children shut down, House is forced to test which drug caused the failure, resulting in one of the babies dying.
Sister Augustine (Elizabeth Mitchell) arrives at the hospital with her hands covered in severe rash, which her fellow nuns think looks like stigmata and which House diagnoses as dermatitis caused by a dish soap allergy.
After returning from jogging with his best friend, Ed (Dominic Purcell) is uncharacteristically abused by his bedridden wife, Elise (Myndy Crist).
John Henry Giles (Harry Lennix), a legendary jazz musician with ALS, is brought in to be treated by Foreman for pneumonia.
Cameron notices a blood clot, which is removed, and MRI reveals an Arteriovenous malformation which is operated on restoring his ability to walk.
Dr. Foreman believes an uncooperative homeless woman (Leslie Hope) is faking seizures to get a meal ticket at the hospital.
Remorseful for his disbelief in the patient's story, Foreman searches for her family with Wilson, eventually discovering that the woman became homeless after losing her husband and son in a car accident two years earlier.
While trying to figure out why a young patient (Nicholas D'Agosto) will not stop bleeding after getting into a car wreck with his girlfriend (Amanda Seyfried), House accepts Cuddy's challenge and goes off Vicodin for a week in exchange for no clinic duty for a month.
A severely broken arm reveals a bizarre case of bone loss and ends the comeback plans of major league pitcher Hank Wiggen (Scott Foley).
Eventually House finds out the wife suffers from loss of smell, indicating the pair have smoked cannabis which was grown on cadmium polluted soil.
After consulting a Ouija board, a young boy (Daryl Sabara) believes he is going to die, and is sent to Princeton-Plainsboro after suffering from pneumonia.
Billionaire entrepreneur Edward Vogler (Chi McBride) donates $100 million to Princeton-Plainsboro, officially becoming the new Chairman of the Board.
Vogler intends to turn the clinic into a profitable venue for his biotech venture and also plans to eliminate House's financially draining department for good.
House is placed under a court order to determine what is ailing a mobster (Joey Arnello, played by Joseph Lyle Taylor) due for federal testimony and the Witness Protection Program.
A popular U.S. senator (Joe Morton) and presidential candidate succumbs to illness at a fundraiser and Vogler assigns House to his case.
A pregnant woman (Marin Hinkle)[27] arrives at the hospital with brain and kidney problems and House must contend with her condition and Vogler's eagerness to see the doctor removed by using the board members.
The patient and her husband must decide between her life and their unborn child's, after the team discovers small cell lung cancer.
The team celebrates Vogler's departure with champagne as Cuddy reminds House this conflict was unnecessary but caused by his temperament.
House fights off a meningitis outbreak and Cuddy gives his team an hour to produce results after he singles out a young patient (Skye McCole Bartusiak)[29] who does not quite fit the criteria.
In the meantime, Cuddy forces House to give a lecture to medical students on diagnosing patients and presents three scenarios, each with different reasons for their leg pain (with guest star Carmen Electra).
After confiding in Stacy that he still has feelings for her, House realizes that Mark had experienced delusions, and actually suffered from acute intermittent porphyria (AIP).
However, Universal reissued the Season 1 set on February 10, 2009, in the correct anamorphic widescreen aspect ratio, which is now on 6 single-sided discs instead of the 3 double-sided ones.