Cuscohygrine is a bis N-methyl pyrrolidine alkaloid found in coca plants.

It can also be extracted from plants of the family Solanaceae, including Atropa belladonna (deadly nightshade) and various Datura species.

Cuscohygrine usually occurs along with other, more potent alkaloids such as atropine or cocaine.

Cuscohygrine, along with the related metabolite hygrine, was first isolated by Carl Liebermann in 1889 as an alkaloid accompanying cocaine in coca leaves (also known as Cusco-leaves).

The condensation of the pyrrolinium salt with acetoacetyl coenzyme A yields hygrine.