Cussewago Creek is a 35.08 mi (56.46 km) long tributary to French Creek that is classed as a 4th order stream on the EPA waters geoviewer site.

[5] Cussewago Creek rises north of Eureka Springs in Erie County, Pennsylvania and flows south into Crawford County, Pennsylvania to meet French Creek at Meadville.

Cussewago Creek drains 97.29 square miles (252.0 km2) of Erie Drift Plain (glacial geology).

The watershed receives an average of 45.4 in/year of precipitation and has a wetness index of 492.71.

Cussewago Creek supports a diverse fauna, including mammals, amphibians, fishes, and mollusks.