Cynthia Burrows

Her research team (consisting of organic, biological, analytical and inorganic chemists) focuses on chemical processes that result in the formation of mutations, which could lead to diseases (such as cancer).

Burrows focuses on the damage found in human telomeric sequences, crucial chromosomal regions that provide protection from degradation and are subject to problems during DNA replication.

[7] Additionally, Burrows’ research in altering nucleic acid composition can provide valuable information in genetic diseases as well as manipulating the function of DNA and RNA in cells.

Nanopore technology is significant in analysis of biological macromolecules such as DNA and RNA because it can detect minute sample quantities and bypasses the need for PCR amplification.

[8] In the context of DNA-protein cross linking, 8-oxoguanine is susceptible to forming adducts with amino acids containing reactive groups such as the phenol moiety of tyrosine or terminal amine of lysine.

DNA can be damaged by the disruption of base pairs.
The Burrows research lab focuses on detecting guanine oxidation reaction as shown.
DNA strand passes through the a-hemolysin nanopore and allows researchers to detect single base damaged site. The goal of this nanopore detection system is to locate damaged sites and understand how a damage at a specific site leads to disease.