Cytidine diphosphate glucose, often abbreviated CDP-glucose, is a nucleotide-linked sugar consisting of cytidine diphosphate and glucose.

[1][2] This nucleotide saccharide participates in the synthesis of deoxy sugars such as paratose and tyvelose.

[3] CDP-glucose is produced from CTP and glucose-1-phosphate by the enzyme glucose-1-phosphate cytidylyltransferase.

[3] CDP-glucose is an important metabolite in certain bacteria, which synthesize O antigens from it.

[3] CDP-glucose can also be used as a substrate for glycogenin, along its native substrate, UDP-glucose.