Recent evidence suggests that it plays a major role in leading strand DNA synthesis and nucleotide and base excision repair.
[1][2] Research had conducted to study nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA (proliferating cell nuclear antigen), RFC (replication factor C) and RPA (replication protein A).
In addition, it only produces small amount of fractionated DNA ligated products.
DNA polymerase epsilon proves to be best suited for nucleotide excision repair.
It is also found that under one condition where DNA polymerase epsilon require PCNA and RFC: nucleotide excision repair in the presence of single strand binding protein RPA.