DNase I hypersensitive site

In these specific regions of the genome, chromatin has lost its condensed structure, exposing the DNA and making it accessible.

The remaining 95% represented distal DHSs, divided in a uniform way between intronic and intergenic regions.

This technique is based in the physical association that exists between the promoter and the enhancers, determining the regions of chromatin that enter in contact in the promoter/enhancer connections.

The number of distal cis-regulatory elements connected to a promoter is related to the quantitative average of the regulation complexity of a gene.

This indicates that the complex of cellular and environmental signals processed by the immune system is directly encoded in the cis-regulatory architecture of its constituent genes.