She is the daughter of Pearl Lowe, the singer-songwriter turned textile and fashion designer, and Gavin Rossdale, lead singer of the rock band Bush.

[5] She grew up in Primrose Hill, North London, and stayed with grandparents to continue her education at South Hampstead High School, when her mother, Pearl Lowe, moved to Hampshire.

Lowe has two younger half-brothers and a half-sister from her mother's marriage to Danny Goffey: Alfie, Frankie, and Betty.

In September 2006, Lowe modelled for the Urban Outfitters catalogue, appeared in French Connection printed advertisements and was profiled in British Harper's Bazaar.

[14] On the runway, Lowe was selected by Karl Lagerfeld to model for Chanel, and has appeared on catwalks in New York, Milan and London for Topshop and designers such as PPQ, Nanette Lepore, Sue Stemp, Charlotte Ronson, Henry Holland, and Vivienne Westwood.

She has modelled for Agent Provocateur lingere for the past three years, and has been used by Burberry, Converse shoes, Dr. Martens, Hooch, Wheels and Doll Baby, Ben Sherman, Frost French, Hari, Karen Millen, Diesel SpA and Whistles, as well as for her mother's recent collection of lace dresses.

Lowe has some experience in other media, including being the focus of the BBC Two eight-part fly on the wall documentary series Class of 2008, co-hosting Glamour's Best Dressed 2008 with Peaches Geldof for Fiver, and a brief contribution to a blog for Elle UK online.

Lowe has worked as a DJ, appeared in the music videos "NYC Beat" by Armand Van Helden and "Bloodthirsty Bastards" by Dirty Pretty Things, and hosted events for Tommy Hilfiger and Dolce and Gabbana.

[31][32] In October 2022, Lowe announced that she was expecting her first child with fiancé Jordan Saul, a real estate developer.