Lee was born in Montreal, Quebec, in 1969, the youngest of four children of Chinese immigrants and grew up in Scarborough, Ontario, a suburb of Toronto.
He graduated with honours from the animation program at Sheridan College in Oakville, Ontario.
He worked on television cartoons and commercials for several studios, including Kennedy Cartoons in Toronto and Colossal Pictures in San Francisco before joining Pixar in June 1996.
He worked as an animator on Darkwing Duck and Goof Troop while at Kennedy Cartoons.
Lee died on January 15, 2005, in Berkeley, California, at the age of 35 years old, from heart failure and lung cancer-related complications.