In 2017, he published the paper Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70[6] in the Journal of Experimental Medicine.

[12] In 2014, he completed a fellowship in infectious diseases from North Shore-Long Island Jewish Health System-Hofstra University in Manhasset.

[13] Griffin's work includes investigating the potential role of human B1 cells and natural antibodies in the development of HIV-associated malignancies.

[16][17] Griffin has volunteered with the nonprofit Foundation for International Medical Relief of Children, including conducting mandatory health education sessions for its staff.

[citation needed] He is an associate research scientist in Columbia's Department of Biochemistry and Molecular Biophysics, instructor of clinical medicine, and a member of the division of infectious diseases.