After graduating from the University of Central Florida with a degree in marketing, Tosh moved to Los Angeles to pursue a career in comedy.

[4] Born in Boppard, Rhineland-Palatinate, West Germany to American parents,[5] Tosh grew up in Titusville, Florida, the son of a Presbyterian minister.

[7] Tosh moved to Los Angeles, but attributes his decision to work in comedy to being raised in Florida, which he considers "flat, hot, and dumb.

He made appearances on programs such as The Tonight Show with Jay Leno, Jimmy Kimmel Live!, and Comedy Central's Premium Blend.

[10] He hosted a local late-night comedy show in Florida called Tens,[11][12] and served as a spokesman in Taco Bell commercials.

[15] He played a fictional version of himself on "Elevator" produced by HBO's Runawaybox[16] and had a small role as Cowboy Hat in the feature film The Love Guru starring Mike Myers.

[19] His special, Daniel Tosh: Happy Thoughts, premiered on Comedy Central on March 6, 2011, with 3.25 million viewers and a 1.9/5 share.

[25] In 2013, Forbes estimated Tosh's net worth at $11 million, tied for ninth place in its list of all top-earning comedians whose income is primarily from stage ticket sales.

[26] Tosh's Comedy Central television show Tosh.0 premiered on June 5, 2009, based on showcasing Internet video clips.

[27] His mocking humor is described as "envelope pushing" and frequently features punchlines that are intentionally self-deprecating, racist, sexist, or homophobic.

He uses a common podcast format, featuring guests in studio, with Eddie, his neighbour from Tahoe that also co-created Tosh.0, behind the camera that chimes in, and video clips from the internet.

[37][38] He has hosted an annual stand-up show called "Tosh Saves The World" which has featured comedians such as Bo Burnham, Chelsea Peretti, Hannibal Buress and Kumail Nanjiani, with the proceeds going to various charities.