Loveline is a syndicated radio call-in program in North America, offering medical and relationship advice to listeners, often with the assistance of guests, typically actors and musicians.

After a hiatus, the show was rebooted as a podcast with Amber Rose and clinical psychologist and sex therapist Chris Donaghue as hosts.

On November 1, 2018, Loveline was revived on LGBTQ network Channel Q with Dr. Chris Donaghue as the solo host, heard Monday through Thursday from 7 to 9 p.m. Eastern Time.

Channel Q is owned by Audacy, Inc. and heard on the company's namesake streaming service and on the HD Radio subchannels of about 20 FM stations in New York City, Los Angeles, Chicago and other large media markets.

In 1984, Trenton added a segment called "Ask a Surgeon," hosted by his friend Drew Pinsky, who at the time, was a fourth-year medical student at the University of Southern California.

As Loveline developed and increased its audience, Pinsky became a public figure in his own right, and the show began referring to him informally as "Dr. Drew".

After Carolla's departure, he was substituted on a temporary basis by numerous celebrity guests, some of whom announced their desire to take the job permanently.

During his first appearance on Carolla's new morning show, Pinsky revealed that the shortlist of candidates included Carson Daly, Joel McHale, Danny Bonaduce, Steve-O and Daniel Tosh.

On April 22, 2009, Stryker announced that due to financial cutbacks at Westwood One, he would be leaving the show and it would be his last appearance that night.

A third incarnation of the show debuted on December 15, 2024, hosted by KROQ personality Kevan Kenney and Tara Suwinyattichaiporn, who is not a medical doctor but has a PhD in human communication.

[13] Furthermore, the comedy is often necessary to keep spirits high, as the show frequently handles callers who are dealing with serious issues such as drug addiction, sexual abuse, and domestic violence.

Whether it be conversations with hosts and guests or specific "radio drops" that they have produced usually from clips of previous shows.

It followed the same general format as the radio program but featured a live audience and a female co-host alongside Pinsky and Carolla.

The female co-host role was filled over the course of the series by MTV VJ Idalis, actresses Kris McGaha, Catherine McCord, Diane Farr and comedian Laura Kightlinger.