Through Violent Lifestyle, Way was introduced to Marvel Comics editor Axel Alonso, who hired Way for a Deathlok mini-series that was cancelled prior to publication.

[2][3] Way's first published work for Marvel was a two-part storyline in Spider-Man's Tangled Web,[4] followed by Gun Theory, a mini-series with artist Jon Proctor under the revived Epic Comics imprint that was cancelled after only two issues.

Way continued to work for Marvel; his subsequent work for the publisher includes Wolverine, Agent X, Venom, Sabretooth: Open Season, Bullseye: Greatest Hits, Ghost Rider, The Incredible Hulk, Supreme Power: Nighthawk and Wolverine: Origins.

", which saw the return of Bob, Agent of HYDRA, and "Magnum Opus", a four-issue crossover with Thunderbolts.

[9] In addition to writing the ongoing Deadpool series for four years, Way also contributed the script for the Deadpool video game, developed by High Moon Studios and published by Activision in 2013,[10] the same year Way wrote the new volume of the Thunderbolts series launched a part of the company-wide Marvel NOW!