[1] In 1998, he teamed up with fellow animator Harper Jaten to create the absurdist humor series Captain Dingleberry, which, after four issues of self-publishing, was picked up by SLG Publishing.

[15][16] At the same time, Remender began working for Marvel as a writer, joining Matt Fraction on Punisher War Journal and staying with the character to launch the new volume that tied in to the status quo resulting from the events of the 2008-09 "Dark Reign" storyline.

[22] In 2013, he returned to Image, producing a slate of creator-owned titles such as Black Science with Matteo Scalera, Deadly Class with Wes Craig, Low with Greg Tocchini, Tokyo Ghost with Sean Gordon Murphy, Seven to Eternity with Jerome Opeña and Death or Glory with Bengal.

[23] In addition to his work in comics and video games, Remender served as the showrunner on the Sony Pictures Television adaptation of his series Deadly Class which aired on Syfy, but was canceled after one season.

[24] In October 2023, it was announced that Giant Generator had signed exclusivity deals with 12 high profile artists including Daniel Acuña, André Lima Araújo, Paul Azaceta, Bengal, Roland Boschi, Max Fiumara, Mike Hawthorne, J. G. Jones, Francesco Mobili, Brett Parson, and Yanick Paquette.

Holy Roller about a pro bowler who is forced to quit his dream job and return to his hometown, which he soon discovers has been overrun by Neo-Nazis, leading him to become a trick bowling ball-wielding Jewish superhero.