It is also used in the management of neuroleptic malignant syndrome, muscle spasticity (e.g. after strokes, in paraplegia, cerebral palsy, or patients with multiple sclerosis), and poisoning by 2,4-dinitrophenol[9][10] or by the related compounds dinoseb and dinoterb.

[11] The most frequently occurring side effects include drowsiness, dizziness, weakness, general malaise, fatigue, and diarrhea.

[14] If needed in pregnancy, adequate human studies are lacking, therefore the drug should be given in pregnant women only if clearly indicated.

[18] Dantrolene was widely used in the management of spasticity[19] before its efficacy in treating malignant hyperthermia was discovered by South African anesthesiologist Gaisford Harrison and reported in a landmark 1975 article published in the British Journal of Anaesthesia.

[4][23] The applicant for this medicinal product is Norgine B.V.[4] In the formulation of Agilus, the mannitol and sodium hydroxide have been replaced with hydroxypropyl-beta-cyclodextrin (HP-β-CD) and Macrogol 3350 to shorten the preparation time and improve the ease of use.