[12] Thiocolchicoside administration also leads to a reduction in muscle spasm during palpation, an improvement in the overall assessment of patients with low back pain, and an enhancement in their ability to perform daily activities.

[12][13] When thiocolchicoside is added to standard nonsteroidal anti-inflammatory drug (NSAID) therapy in lower back pain, such therapy reduces pain intensity and improves functional status according to the average estimates of visual analogue scale (VAS) and life disorders questionnaires.

[12][13] Several medicines, including tolperisone, aceclofenac plus tizanidine, and pregabalin, are effective in reducing pain intensity.

Human data are limited to a follow-up of about 30 pregnant women (no major malformations) and reports of altered spermatogenesis, including cases of azoospermia.

[7] Thiocolchicoside is broken down in the body to a metabolite called 3-demethylthiocolchicine (also known as SL59.0955 or M2) that could damage dividing cells therefore inducing toxicity in the embryo, neoplastic changes and fertility reduction in males.