With the construction of the Darmstadt Hauptbahnhof from 1909 to 1912, the Main-Neckar Railway was shifted to the west and lowered and a new Darmstädt South station was built.

[4] The new station was designed in neoclassical and traditional styles by the architect of the Mainz railway division (Eisenbahndirektion), Friedrich Mettegang.

The upper building is topped by a hip roof, and on the east side it has a "bat" dormer (Fledermausgaube) with a central round clock.

The dormer windows have wood paneling, decorated by tapes and diamond motifs and turned round columns.

Since the timetable change of 2011/2012 on 11 December 2011, the station has been served by the Regionalbahn RB 66 (the Pfungstadtbahn) from Darmstadt to Pfungstadt.