[1] Leimbach Park and the Wiesloch Feldbahn and Industrial Museum are located to the north of the station, with the headquarters of Heidelberger Druckmaschinen and SAP SE on the south-western side.

The Karlsruhe—Heidelberg section of the Rhine Valley Railway was opened on 15 April 1843 as part of the construction of the Baden Mainline from Mannheim via Heidelberg, Karlsruhe, Baden-Baden and Freiburg to Basel, which was initially built to 1600 mm broad gauge.

Therefore, in 1854, Baden began to regauge its lines to 1,435 mm (4 ft 8+1⁄2 in) standard gauge and this was completed in just four months from Mannheim to Bruchsal.

Since the station is located about three kilometres from both Wiesloch and Walldorf, both towns only gained a limited benefit from the line.

On Sunday 18 January 1959 a North American F-100 Super Sabre crashed a couple of hundred metres from the station.