[2] Researchers identified the nematode as a possible host because they feed on insects by targeting their larvae and releasing bacteria that then confront pathogens similar to those found in humans.

[1] In experiments, it cured mice of infections with Escherichia coli and Klebsiella pneumoniae, both members of the Enterobacteriaceae, without toxic side effects.

Antibiotic resistance has become widespread in bacterial pathogens, and in Gram-negative bacteria such as the Enterobacteriaceae, much of this comes from acquired genes.

The resistance genes encode proteins that export or inactivate β-lactam antibiotics, aminoglycosides, tetracycline, chloramphenicol, fosfomycin, etc.

Mature darobactin consists of a seven amino acids core peptide derived from a longer precursor, with unusual Trp-1 to Trp-3 and Trp-3 to Lys-5 (or Arg-5, in variant forms) crosslinks.