During World War II, Breese entered Pre-Flight Training at Lane Tech, in the hope of serving his country.

Though Breese had no interest in religious pursuits, he heard a woman clearly present a Gospel message while teaching on the Holy Bible's Book of Romans.

[3] Breese, who always desired to learn how to fly, earned a "multiengine rating" and, in the years that followed, he flew himself to speaking engagements all across the country.

[2] Breese was a member of Youth for Christ throughout the 1950s, and later became the Executive Director of the movement's Chicagoland chapter, giving a speech entitled "Global Struggle for Minds of Men" to a Chicago crowd in December 1963.

[2] Breese was eventually succeeded as president of Christian Destiny Ministries, and later on he became a strong critic of progressive dispensationalism, which he believed had taken over many mainstream evangelical churches, but was not biblically sound.

[7] Around the time of the Moral Majority's onset in the 1980's, Breese told an audience at the National Association of Evangelicals that: "It no longer fits to picture us as redneck preachers pounding the pulpit.

"[8]In the Anti-Mormon film The God Makers II, Breese makes an appearance in which he criticises the LDS Church and its doctrines.

His sister, Betty, has told of how in his early years his mother would have a young Dave Breese recite poetry.

In an average year, he would travel over 100,000 miles to speak at churches, Bible conferences, colleges, universities, evangelistic meetings and debates.