[citation needed] Piwnica-Worms completed his residency in diagnostic radiology and a fellowship at Brigham and Women’s Hospital, followed by faculty appointments at Harvard Medical School.
His work primarily involves genetically encoded bioluminescent and radiotracer reporter systems to study signal transduction, protein interactions, and gene expression in various biological contexts, including single cells, cell populations, and live animals.
[2] His past research interests also included the function and regulation of the multidrug resistance P-glycoprotein family of transporters.
He currently leads translational research efforts using cell-penetrating peptides for fluorescence imaging applications in the eye.
[5] His lab has also discovered and is advancing novel ligands and antibodies into the clinic for imaging and beta-radioligand therapy applications (theranostics) targeting B7H3, a receptor expressed on many tumors.