Dazoxiben is an orally active thromboxane synthase inhibitor.

[1] It has shown a significant clinical improvement in patients with Raynaud's syndrome.

[2] One convenient synthesis starts with the O-chloroethyl ether of p-hydroxybenzamide and proceeds bydisplacement with imidazole to give 2.

Hydrolysis of the amide function completes the synthesis of dazoxiben.

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