He played in the National Basketball Association (NBA) for 7 seasons with the Spurs, Dallas Mavericks and Washington Wizards.

[1] Although he was the smallest of his siblings at birth, he was the largest child in his class by the time that he started at Manchester Academic Charter School, where he attended kindergarten through eighth grade.

[1] After two surgeries during his high school years, Blair was left without any anterior cruciate ligaments (ACLs) in his knees.

Besides Pitt, other schools pursuing him included Florida, Kansas State, Indiana, Marquette, Miami, West Virginia, Wake Forest, and Tennessee.

His parents admitted that if they had their way, Blair would have gone to Tennessee because they liked the Volunteers' coach Bruce Pearl, and thought it would be a good idea for their son to leave the city.

Blair himself had problems making up his mind; while considering as many as 18 different scholarship offers, he was so confused that one day he threw his cell phone across a room, breaking it.

The Panthers won their first-round game against Oral Roberts, but lost in the second round to fifth-seeded Michigan State.

Blair and Connecticut center Hasheem Thabeet shared co-Big East Player of the Year honors for the 2008–09 season.

He later recorded 28 points and 21 rebounds in 31 minutes against the Oklahoma City Thunder on January 13, 2010, becoming first NBA rookie since Tim Duncan in the 1997–98 season to post a 20–20 game.

Sacramento Kings guard Tyreke Evans won the game MVP award, but graciously offered to share it with Blair.

The addition of Boris Diaw and emergence of Tiago Splitter led to reduced playing time for Blair and, ultimately, a loss of his starting position during the 2012–13 season.

Blair made his displeasure clear as the season progressed and eventually played a minimal role in the Spurs' rotation.

[16] In 2014–15, Blair appeared in a career-low 29 games (his previous was 61) and failed to make a start for the first time in his six-year career.

[17] On February 18, 2016, Blair was traded, along with Kris Humphries and a 2016 protected first-round draft pick, to the Phoenix Suns in exchange for Markieff Morris.

[23] On February 11, 2017, Blair was traded by the Legends to the Los Angeles D-Fenders in exchange for a 2017 fourth-round draft pick.