Jerebko played a total of 10 seasons in the NBA with four different teams, the Detroit Pistons, Boston Celtics, Utah Jazz and Golden State Warriors.

In May 2009, ESPN analyst Fran Fraschilla considered Jerebko one of the top five European prospects in the 2009 NBA draft.

His career in the NBA got off to a rough-and-tumble start; in a preseason game, Jerebko was accused of punching Miami Heat center Jamaal Magloire in the face.

He was among NBA rookie leaders ranked third in rebounds, fourth in blocks (0.36 bpg), fifth in minutes (27.9 mpg), eighth in steals, 10th in scoring and tied for 18th in assists.

[12] On November 13, he posted his 11th career double-double with season bests of 14 points and 14 rebounds in a 110–103 win over the Atlanta Hawks.

[13] On December 22, he scored a career-high 23 points on 10-for-12 shooting with six rebounds in 21 minutes off the bench in a 120–116 win over the Dallas Mavericks.

The news of the signing, which occurred one month after the start of the Russian invasion of Ukraine, was met with widespread criticism in his home country Sweden.

Following his decision of joining CSKA Moscow in the spring of 2022, Jerebko was expelled by the Swedish national team.

[24] On August 26, 2016, Jerebko purchased the Renegades esports organization from Chris Badawi and Christopher "MonteCristo" Mykles.