He played college football for the Louisville Cardinals and was selected by the Miami Dolphins in the first round of the 2015 NFL draft with the 14th overall pick.

He attended Ballard High School in Louisville, Kentucky,[1] where he was a three-sport star in football, track and basketball.

He was named co-Paul Hornung Award winner as the state's top player with Boyle County's Lamar Dawson.

He finished his career as one of the state's all-time leading wide receivers with 3,274 yards, which ranks fifth only behind Somerset's John Cole (4,981), Lawrence County's Gerad Parker (4,736), Male's Montrell Jones (4,345) and Mason County's Chris Lofton (3,511).

He earned a third-place finish in the 100-meter dash at the 2011 Male All Comers Meet, recording a personal-best time of 11.18 seconds.

[3] At the 2011 Class 3A Region 4 Championship, he posted a career-best time of 22.57 seconds in the 200-meter dash, placing 3rd, while also helping his 4x100 relay rank top in the state until defeated by rival Louisville Eastern High School at regionals and 4x200 relay squad placed first.

He was ranked as the 77th-best wide receiver nationally by Rivals.com and the fifth-best player in the Rivals.com Kentucky postseason top 10.

[6] He also made a highlight-reel 39-yard touchdown reception in the season-opening win versus Murray State.

[7] As a sophomore in 2012, Parker played in all 13 games and led the team with 744 receiving yards and 10 touchdowns on 40 receptions.

In Week 12, against the New York Jets, he had his first professional receiving touchdown on a 33-yard reception from quarterback Ryan Tannehill.

[23] In 2016, Parker started off his second professional season strong with eight receptions for 106 receiving yards against the Patriots in Week 2.

[31] In Week 4 against the Los Angeles Chargers, Parker caught four passes for 70 yards and one receiving touchdown in the 30–10 loss.

[35] In Week 16 against the Cincinnati Bengals, Parker caught five passes for 111 yards and a touchdown during the 38–35 overtime win.

[38] In Week 4 of the 2020 season against the Seattle Seahawks, Parker recorded ten catches for 110 yards during the 31–23 loss.

[39] In Week 8 against the Los Angeles Rams, Parker caught the first career touchdown pass thrown by rookie quarterback Tua Tagovailoa during the 28–17 win.

[50] In the following game, Parker scored his first touchdown as a Patriot in the 27–24 overtime loss to the Green Bay Packers.