Playing as Blob, players embark on a quest to re-animate the fictional Chroma City and free it from the INKT Corporation by splattering buildings, landmarks, and citizens with color.

de Blob is free to roll around and collect paint from Paintbots in the three colors of red, yellow and blue, which can be combined into green, orange, purple and brown.

As he colors the city, the game's soundtrack, featuring live bands which recorded slow and fast versions of each "lick" (each hit), gradually adds more instrumentation as well as an additional "layer" of sound corresponding to de Blob's current color—being red usually adds a saxophone solo to the music, for example.

Chroma City quickly falls to the invading army of Inkies and color-draining Leechbots, leaving its landscape barren, its flora withered and its fauna in hiding.

The citizens are rounded up and turned into "Graydians", encased in homogeneous gray prison suits distinguished only by a bar code on the back of each shell.

Blob witnesses the takeover of Chroma City from his jungle retreat and goes into action, first rescuing the only remaining pocket of resistance, the Color Underground.

Blob joins the group, and under their orders, begins to win back sections of the city and arouse the vicious ire of Comrade Black.

In response, Black orders everything from propaganda campaigns to the creation of super soldiers in an attempt to stop Blob, though to no avail.

However, Blob manages to stowaway onto the spaceship and defeat Black, then detonates a device that devours the spacecraft in a burst of color and whimsy while escaping on a Hoverboard.

A post-credit scene reveals that Comrade Black survived the destruction of his spaceship and is now trapped on a tiny island populated by cute and colourful creatures, much to his chagrin.

It was primarily intended for short-duration play, keeping people entertained for at least a few minutes at a booth while learning about the city's plans for the station.

The developers also stated that they had used 3D Studio MAX for modeling-level designs, Adobe Photoshop for textures, and Reason and Sound Forge for audio.

[29] It was nominated for several other Wii-specific awards by IGN, including Best New IP,[30] Best Original Score,[31] Most Innovative Design,[32] and Game of the Year.

[38] During THQ's fiscal third quarter conference call, president and CEO Brian Farrell announced both de Blob and Saints Row would see new titles in the coming years.