The film features an ensemble cast of horror icons including Kane Hodder, Barbara Crampton, Bill Moseley, Dee Wallace, Tony Todd and Camille Keaton.

Upon arrival, Boon is taunted by neo-Nazi criminal Alois Sieg, who she went undercover to capture, but killed a mother and her son to keep her cover.

Fletcher introduces Novak and Boon to her colleague, Dr. Karen Redmane, who explains that Death House uses drugs, machines, and simulations to keep inmates such as "Leatherlace" and "the Icicle Killer" docile.

Reasoning that the Five Evils offer the best chance of escape, Boon and Novak descend down an elevator shaft to the facility's lowest level.

When confronted, prisoner Hirace Giger explains that there are multiple Death Houses being used to breed a new race that is neither good nor evil with technology as their new god.

The most notable horror icons confirmed include Kane Hodder, Barbara Crampton, Bill Moseley, Dee Wallace, Camille Keaton, Sid Haig, Felissa Rose, Tony Todd, Adrienne Barbeau, and Michael Berryman.

[12] Michael Gingold of Rue Morgue Digital criticized the film's look and story, saying that "the horror content consists largely of poorly shot action that is sometimes so underlit that you can’t tell what’s going on" and "Death House’s only value is as a game of Spot-the-Celebrity - which at least provides a distraction from the tackiness of the plotting and filmmaking.

"[13] In contrast, Michelle Swope of Dread Central rated the film 4.5 out of 5 stars, admitting "Not all of the performances are standout, but the bloody pandemonium and creative writing make this a damn good movie worthy of becoming a cult favorite.