Guests have included Phill Jupitus, Sara Pascoe, Russell Tovey, Mike McShane and Hannibal Buress.

[17] In 2015 she created The Beau Zeaux a long-form improvised comedy featuring a rotating cast including Marcus Brigstocke, Thom Tuck, Rachel Parris, Brendan Murphy, Ed Coleman, Milly Thomas and Pippa Evans.

Her BBC Radio 4 series Deborah Frances-White Rolls the Dice was first broadcast in spring 2015[20] and featured stories about her adoption, green card marriage, and the quest to find her biological family.

In January 2016, the show won Frances-White the Writers' Guild of Great Britain award for "Best Radio Comedy".

In 2019, The Guilty Feminist and Amnesty International joined forces for the Secret Policeman’s Tour, consisting of three shows with comedy, music and discussion, all in support of human rights.

[24] In 2023, The Guilty Feminist also launched Media Storm, a news podcast hosted by journalists Mathilda Mallinson and Helena Wadia.

[23] She has co-written two books: The Improv Handbook with Tom Salinsky[29] and Off the Mic with Marsha Shandur,[30] both published by Bloomsbury.