Deborah Ann Nickerson (1954 – December 24, 2021)[1] was an American human genomics researcher.

[2][4][5] Nickerson was a founding member of the University of Washington Department of Genome Sciences in 2001.

[2] Nickerson's work focused on the application of genomic technologies to understand genetic variation underlying human health and disease,[5] and advanced the idea of cataloging human genomic diversity to improve genetic discoveries and diagnoses.

[5] Notable work by Nickerson's group included illuminating of the pharmacogenomics of warfarin dosing,[6] and producing early catalogs of normal human genomic variation.

[4] Using exome sequencing, Nickerson also identified the gene for Miller syndrome with her colleagues Michael Bamshad and Jay Shendure.