He is a professor in the Department of Genome Sciences at the University of Washington School of Medicine[1] and an Affiliate Investigator in the Human Biology Division at the Fred Hutchinson Cancer Research Center.

[3][4][5] Shendure's research group at the University of Washington pioneered exome sequencing and its application to Mendelian disorders,[5][6] a strategy that has been applied to identify hundreds of disease-causing genes.

[10][11][12] Shendure graduated summa cum laude from Princeton University in 1996 and completed a Fulbright scholarship at Pune, India, in 1997.

He joined the faculty at the Department of Genome Sciences at the University of Washington in 2007 and was tenured as an associate professor four years later in 2011.

He is also the founding Scientific Director of the Brotman-Baty Institute established in 2017 through a gift from Jeffrey H. and Susan Brotman, and Daniel R. and Pamela L. Baty.