Decoy receptors

Decoy receptors participate in common methods of signal inhibition and are also abundant in malignant tissues, making up a significant topic in cancer research.

Axl receptor tyrosine kinase has been associated with numerous diseases, most notably metastatic cancer.

Axl has been shown to drive metastasis, confer therapeutic resistance and promote disease progression.

Decoy receptors are being designed to bind to Gas6 and prevent Axl activation.

[7] ACE-031 is an engineered decoy receptor and myostatin inhibitor used in attempts to treat children with Duchenne muscular dystrophy (DMD).

Decoy receptors/ bind to ligands and inhibit signaling through actual receptors.