Dedoplistskaro or Dedoplistsqaro (Georgian: დედოფლისწყაროს მუნიციპალიტეტი, 'Queen's spring') is a municipality of Georgia, in the region of Kakheti.

From ancient times the territory of present-day Dedoplistskaro municipality was part of the historical Kambechovani province of Georgia.

At the beginning of the twentieth century, Dedoplistskaro, as an administrative-territorial unit, was part of Sighnaghi Mazra.

The name Dedoplistskaro has been known in historical sources since the eleventh century, when King David the Builder established a military post here.

According to this legend, Queen Tamar visited Kambechovan with David Soslan and lived in Khornabuji for two weeks.

According to the National Statistics Office of Georgia, the population of Dedoplistsqaro Municipality[3] as of 1 January 2021[update] is 20,700 people.

Mostly Georgians, a small number of Armenians, Russians, Azerbaijanis, and other nationalities live in the municipality.

The majority of the municipality is occupied by the Iori highland, which stretches to the extreme south-east part, to the Eldari lowland.

The municipality's territory includes the Gombori ridge south-east ending and also the Alazani lowland part from the village Samtatskaro to the river Agrichai connection.

A number of plant species and animals are also found in the municipality, for example the striped hyena, gazelle, lynx, jackal, fox, wolf, Lelian's cat, badger and others.

The museum mainly preserves clay and bronze materials discovered during archeological excavations in the Dedoplistsqaro area (from the sixth to first centuries BC to the late feudal era): seals, jewelry, medical clayware, bronze tweezers, cult sculptures, buffalo masks, Scythian arrow blades.

There are ethnographic materials such as Qizikian rugs, saddlebags, striped woven cloths, red runners (carpets), gold-embroidered Qajar, and household items.

The museum also keeps the paintings of Georgian artists of the twentieth century (Robert Sturua, A. Popiashvili, J. Gvimradze, R. Tordia, and V. Albirov).

[11] Niko Pirosmanashvili House-Museum is a historical monument located in the Pirosmani district of the village of Mirzaani, Dedoplistsqaro Municipality.

The museum was founded in 1985 and is located in a one-story Russian-style house which was the property of G. Nechvelodov, an officer of the Nizhegorod Dragoon Regiment.

One of the architectural monuments is the early medieval fortress-town of Khornabuji near the town of Dedoplistsqaro, which was the center of the historic Kambechovani district.