He played college football for the South Carolina Gamecocks and was selected by the 49ers in the second round of the 2019 NFL draft.

[3] He won the High School Sports Report Class AAA Offensive Player of the Year, and played in the Shrine Bowl of the Carolinas.

[6] Samuel played in five games total, making three starts and struggling with injuries.

[12] In Week 3 against Kentucky, on the first play from scrimmage Samuel caught a 68-yard touchdown pass from Gamecock quarterback Jake Bentley.

[14] It was announced after the game by head coach Will Muschamp that Samuel had broken his right fibula and would miss the rest of the season.

You can use this moment to show people how to overcome adversity, the whole state of South Carolina loves Deebo.

[28] Deebo Samuel made his NFL debut against the Tampa Bay Buccaneers, catching three passes for 17 yards and losing a fumble in the 31–17 road victory.

[29] In the next game against the Cincinnati Bengals, he caught five passes for 87 yards and his first NFL touchdown as the 49ers won on the road by a score of 41–17.

[31] Two weeks later against the Seattle Seahawks on Monday Night Football, he caught eight passes for 112 yards in the 27–24 overtime loss.

[32] In the next game against the Arizona Cardinals, Samuel caught eight passes for 134 yards in the 36–26 victory.

[33] Samuel would have two more touchdown catches over the next two games against the Green Bay Packers and Baltimore Ravens, and would add another rushing score in the Week 16 contest against the Los Angeles Rams.

[35] Samuel was placed on the non-football injury list at the start of training camp on July 28, 2020.

[43] During the season-opening 41–33 road victory over the Detroit Lions, Samuel caught nine passes for 189 yards and a touchdown.

[46] Over the course of the season, the 49ers increasingly lined Samuel up in the backfield like a traditional running back, roughly 11% of the time,[47] in order to get the ball in his hands more often and take advantage of his play-making ability.

[56][57] Against the Rams in Week 4, Samuel had six catches for 115 yards and a touchdown on a 57-yard catch-and-run in the 24–9 win.

[62] He recorded six receptions for 133 yards and a receiving touchdown in the Wild Card Round win over the Seahawks.

[68][69] This occurred due to the events of the 2023 NFC Championship from the prior year, where Samuel was held to 3 catches in the 31–7 loss.

[74] Samuel played in Super Bowl LVIII and caught three passes for 33 yards, but the 49ers lost to the Chiefs 25–22 in overtime.