Skule was a two-year starting left tackle for Centreville High School.

[2] Skule was nearly a four-year starter on the offensive line for Vanderbilt, missing only five games in his freshman season due to an injury.

[4] In 2019, the 49ers reached Super Bowl LIV, but they lost 31–20 to the Kansas City Chiefs.

On June 7, 2021, Skule suffered a torn ACL during practice, ending his 2021 season.

[8] On September 21, 2022, Skule was signed to the practice squad of the Tampa Bay Buccaneers.