Defence struck three times on the south end of the bank near Batacalo, but quickly got into deep water.

[3] 2nd EIC voyage (1738–1740): Captain Thomas Coates sailed from the Downs on 8 November 1738, bound for Mokha and Bombay.

Defence reached the Cape of Good Hope on 25 January 1739 and arrived at Mokha on 15 April.

[2] 3rd EIC voyage (1742–1743): Captain Coates sailed from the Downs on 9 February 1742, bound for China.

Homeward bound, she crossed the Second Bar on 25 January 1743, reached St Helena on 1 May, and arrived back at the Downs on 6 August.