Defiance is Village and census-designated place[4] in Broad Top Township, Bedford County, Pennsylvania, United States.

[5][6] It is located along Six Mile Run Road (State Route 1036).

The community most likely was named in pioneer days after Fort Defiance.

[7] Public education in Defiance is administered by the Tussey Mountain School District, which operates Defiance Elementary School within the community.

Defiance Elementary no longer exists due to consolidation by Tussey Mountain School District.