[3][7] Beginning in 1779, the Spanish government began settling Canary Islanders along Bayou Terre-aux-Boeufs and throughout the state of Louisiana to defend New Orleans and the territory against Great Britain.

This original settlement was known as the Población de San Bernardo (St. Bernard Population) and was composed of smaller establecimientos (establishments) or puestos (posts).

[6] Delacroix represented the final community in a long chain leading all the way to the western limit of Saint Bernard.

[6] Following the American Civil War, many Isleños moved to the easternmost portions of St. Bernard Parish in order to fish, trap, hunt, and gather Spanish moss.

[9] Two years later, over one thousand people, mostly Isleños, perished from the Spanish flu pandemic and were buried at a mass burial site in the St. Bernard Catholic Cemetery.

[11] Due in large measure to the isolation of Delacroix, many Isleño customs and traditions were preserved by community members into the later half of the twentieth century.

[8][7] During this period, various academics visited Delacroix to study the Isleño identity and culture, namely the unique dialect of Spanish used by the community.

The community lies on top of a thin strip of sandy meander belt deposits from the Plaquemines and Balize delta lobes which formed over the last 1,500 years.

[7] Various markers have been installed at the "End of the World" as well as other signage using this phrase but these signs have been consistently replaced due to storm damage or vandalism.