Dendrosomes[1] are vesicular, spherical, supramolecular entities wherein the dendrimer–nucleic acid complex is encapsulated within a lipophilic shell.
They possess negligible hemolytic toxicity and higher transfection efficiency, and they are better tolerated in vivo than are dendrimers.
Poly (propyleneimine) dendrosome based genetic immunization against Hepatitis B was found to be highly effective as compared to Dendrimer-Plasmid DNA complex.
Moreover, it has been hypothesized that the lipoidal layers of the dendrosomes modifies the release pattern of the poly (propyleneimine) dendrimer –DNA complex, while some of the larger vesicles remain at the site of injection following their degradation by tissue phospholipases, the smaller ones delivering and transfecting efficiently the antigen-presenting cells (APC) in the draining lymph nodes.
It has been reported that polyamidoamine dendrimer based dendrosomes are efficient systems for the delivery of siRNA for effective management of cervical cancer.