Depauville is a hamlet and census-designated place (CDP) in the southern region of the town of Clayton, within Jefferson County, New York, United States.

[4] The squatters that inhabited this area were often called "Catfish People", marking their settlement from the clearing of trees establishing its boundaries.

In 1816, merchant Francis Depau purchased several lots in Penet Square including Catfish Falls, later renaming the settlement "Depauville" after himself.

[3] The ship was large enough to raise concerns on its capability to navigate the shallow waters of the Chaumont River before reaching Lake Ontario.

Depauville's first Fire District was created in 1932 and during the Great Depression housed a camp of the Civilian Conservation Corps (CCC).

The CCC established a headquarters consisting of ten camps at the Madison Barracks in Sackets Harbor.

Depauville in January 1998 witnessed one of the most destructive natural disasters that Jefferson County had ever endured, the Ice Storm of 1998, 36 hours of freezing rain that left damaged homes and properties, impassable roadways and many people powerless and hungry for weeks.

Depauville provides community events held at each of two churches, the fire department banquet hall and public library.

Depauville is a site for hunting and fishing as the salmon spawn and migration includes the Chaumont River from Lake Ontario.