Pamelia Center is a hamlet and census-designated place (CDP) in Jefferson County, New York, United States.

I-81 leads south 5 miles (8 km) to Watertown, the county seat, and north 25 miles (40 km) to the Canada–United States border at the St. Lawrence River.

I-781 leads east 5 miles (8 km) to Fort Drum.

According to the U.S. Census Bureau, the CDP has an area of 1.041 square miles (2.70 km2), all land.

This article about a location in Jefferson County, New York is a stub.