It runs northwards from its southern junction with New Cross Road/Deptford Broadway (A2) for approximately 0.5 miles (0.8 km) to Evelyn Street/Creek Road (A200).
The northern half of the street passes under Deptford railway station, operated by Southeastern, on the North Kent Line.
At the end of the 19th / beginning of the 20th century, Deptford High Street was also shaped by German business people for decades.
Brothers Albert and Alfred Stratton killed Thomas and Anna Farrow, an elderly couple who tended George Chapman's oil and colour shop (today a newsagent) during a robbery.
It added:"It’s easy enough to tick off what makes Deptford High Street cool: independent shops, cafés, bars and restaurants.